Asian Journal of Medical Research and Case Reports

Oxaliplatin is a third-generation platinum compound, used in combination with fluoropyrimidine, is indicated for - adjuvant treatment of stage III colorectal cancer (CRC) in patients who have undergone complete resection of the primary tumor and in treatment of advanced colorectal cancer. Nausea, fatigue, anemia, vomiting, diarrhea, increased liver enzymes, peripheral neuropathy, and stomatitis are the common side effects. Serious adverse effects such as - thrombocytopenia, neutropenia, hypersensitivity, etc are also observed. A case of oxaliplatin-induced hypersensitivity reaction in a patient with rectal cancer is described in this article. The patient was prescribed injection oxaliplatin 150mg for chemotherapy treatment along with irinotecan and 5 fluorouracil (FOLFIRINOX regimen). This was the 8^th cycle of the same regimen. The patient developed hypersensitivity during the treatment and the drug was withdrawn and the patient was treated for a hypersensitivity reaction. This case report illustrates oxaliplatin-induced hypersensitivity reaction - a rare and serious reaction in a patient with rectal cancer on chemotherapy.